High-Fat Diet Increases Serum HDL, but Not for LDL and HDL/LDL Ratio in MICE

The use of a ketogenic diet with an increased proportion fat is rampant lately, both as therapy or even lifestyle. feared to cause dyslipidemia. It will also lead atherosclerosis and thrombosis. This study aimed determine the effect high-fat on HDL, LDL, HDL/LDL ratio in mice. Thirty male Mus Musculus, 2-3 mo, 15-25 g divided into five groups diet. K1 (12% fat, 20% protein, 62% carb), K2 (30% 60%protein), K3 (45% 45% protein), K4 (60% 30% protein) K5 (75% 15% for 4 weeks. Feed water by adlibitum. Blood serum was taken from ventricle, while measurement HDL level, LDL used ELISA. Normality data analyzed Shapiro Wilk, homogeneity Levene test. using equality test followed Games Howell, tested ANOVA LSD significance 0,05. (62,50±9.94) mg/dL, (78,40±18,76) (79,00±3,81) (80,00±2,16) (83,50±5,62) mg/dL p<0,05 K1, K3, K5. (21,67± 4,80) (23,00±12,70) (18,40±4,34) (24,00 ±1,83) (22,00 ± 4,08) p>0,05. Ratio (3,01±0,91), (4,10±1,86), (4,53±1,5), (3,35±0,34), (3,96 1,25)